CBDA is a compound that interacts with the endocannabinoid system. It inhibits the COX-2 enzyme and Id-1 protein and has anti-inflammatory properties. Scientists have been studying CBDA for years. One of the most recent studies looked at CBDA’s potential as an anti-inflammatory agent. Researchers compared the chemical structure of CBDA with nonsteroidal anti-inflammatory drugs.
Interacts with the endocannabinoid system
The ECS comprises an enormous network of cellular receptors and chemical signals. These receptors regulate the levels of neurotransmitters in the body. Endocannabinoids interact with them to maintain homeostasis. It has specialized enzymes that produce endocannabinoids. The cutaneous ECS interacts with TRP receptors, which control pain and sensations. CBDA near me offers topical products attributed to this interaction with the endocannabinoid system.
Various studies have found that cannabinoids amplify the effects of certain pharmaceuticals. For example, vaporized cannabis increases the effects of NSAIDs and opioids. It also increased the effects of blood thinning medications, such as ibuprofen and alcohol.
Inhibits COX-2 enzyme
The COX-2 enzyme is implicated in inflammatory diseases, including rheumatoid arthritis and osteoarthritis. It is also present in the human brain. Moreover, overactive COX-2 enzymes have been linked to neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease.
CBDA inhibits the COX-2 enzyme selectively. The carboxylic acid moiety in CBDA is the determining factor in COX-2 inhibition. Therefore, it is a component of cannabis crude extract. CBDA has phenolic hydroxyl groups, while beta-resorcylic acid has a dibenzopyran ring structure.
COX-2 inhibition was significant in a study of mice. When CBDA was administered to these mice, it inhibited COX-2 expression in neurons and glia. The effect continued for seven days. CBDAYHA induced anti-inflammatory effects.
Inhibits Id-1 protein
Despite its anti-inflammatory qualities, CBDA is still in the early stages of clinical trials. Further studies are needed to determine its effectiveness in treating breast cancer. It also has the potential to inhibit tumor growth. CBDA is a selective Cox-2 inhibitor. Cox-1 is responsible for the lining of the stomach and intestinal tract. Nonsteroidal anti-inflammatory drugs inhibit Cox-1, but they can damage the lining of the digestive tract. CBDA works by inhibiting Cox-2 instead, which avoids significant damage to the stomach lining.
The researchers also found that cannabidiol inhibits the expression of the Id-1 gene in aggressive breast cancer cells. This inhibition appears to be at the promoter level, which is important because breast cancer cells that express this gene are more aggressive. This inhibits tumor growth, invasion, and metastasis.
Inhibits cancer cell metastasis
CBDA suppressed tumor cell metastasis. It decreased phosphorylation at the Ser188 location while increasing phosphorylated RhoA. It did not affect MDA-MB231 cell proliferation overall.
Its antiproliferative activity was observed in MDA-MB-231 breast cancer cells. Moreover, it inhibited the expression of cAMP-dependent protein kinase A and RhoA in human breast cancer cells. Additionally, it inhibited the formation of adipocyte-like stromal cells called MCF-7.
The CB receptors on tumor cells influence cell growth and death. As a result, CBS and estrogen play critical roles in tumor growth. However, their activities are exclusive to tumor cells and depend on the donor type. Furthermore, anticancer effects are affected by cancer type, donor features, and tumor location.
It can be used as an anti-nausea drug.
Many anti-nausea medications contain multiple ingredients. For instance, a serotonin (5-HT3) antagonist and an NK-1 receptor antagonist can be used in a single dose to help treat nausea from both acute and delayed causes. These medications are effective for treating nausea but may have side effects.
It can be used as a culinary ingredient.
The endocannabinoid system is responsible for processing cannabinoids. These compounds are neurotransmitters that travel through the bloodstream and attach to cells. They also have many beneficial effects on the body.
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